Protocol for multiplexed RNAscope-based imaging of mrnas in whole-mount adult drosophila brains.
Wu, M., Lambatan, V., Guo, P., & Joiner, W. J. (2025). 
STAR Protocols, 6(1), 103615. https://doi.org/10.1016/j.xpro.2025.103615

Illuminating understudied kinases: A generalizable biosensor development method applied to protein kinase N.
Bogomolovas, J., & Chen, J. (2025). Communications Biology, 8(1).
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Functional differences between rodent and human PD-1 linked to evolutionary divergence.
Masubuchi, T., Chen, L., Marcel, N., Wen, G. A., Caron, C., Zhang, J., Zhao, Y., Morris, G. P., Chen, X., Hedrick,
S. M., Lu, L.-F., Wu, C., Zou, Z., Bui, J. D., & Hui, E. (2025).
Science Immunology, 10(103). https://doi.org/10.1126/sciimmunol.ads6295

Botulinum Neurotoxin Induces Neurotoxic Microglia Mediated by Exogenous Inflammatory Responses
Ambrin, G., Kang, Y. J., Do, K. V., Lee, C., Signh, B. R., & Cho, H. 
Advanced Science, 2305326–2305326. https://doi.org/10.1002/advs.202305326

EIF5A controls mitoprotein import by relieving ribosome stalling at tim50 translocase mrna.
Barba-Aliaga, M., Bernal, V., Rong, C., Volfbeyn, M. E., Zhang, K., Zid, B. M., & Alepuz, P. (2024). 
Journal of Cell Biology, 223(12). https://doi.org/10.1083/jcb.202404094

CXCL12+ dermal fibroblasts promote neutrophil recruitment and host defense by recognition of IL-17.
Cavagnero, K. J., Li, F., Dokoshi, T., Nakatsuji, T., O’Neill, A. M., Aguilera, C., Liu, E., Shia, M., Osuoji, O., Hata, T., & Gallo, R. L.
Journal of Experimental Medicine, 221(4). https://doi.org/10.1084/jem.20231425

PINK1 controls RTN3L-mediated er autophagy by regulating peripheral tubule junctions.
Chidambaram, R., Kumar, K., Parashar, S., Ramachandran, G., Chen, S., & Ferro-Novick, S. (2024).
Journal of Cell Biology, 223(12). https://doi.org/10.1083/jcb.202407193

Molecular profiling of human blastocysts reveals primitive endoderm defects among embryos of decreased implantation potential
Chousal, J. N., Morey, R., Srinivasan, S., Lee, K., Zhang, W., Yeo, A. L., To, C., Cho, K., Garzo, V. G., Parast, M. M., Laurent, L. C., & Cook-Andersen, H.
Cell Reports, 43(2), 113701. https://doi.org/10.1016/j.celrep.2024.113701

A designed ankyrin-repeat protein that targets parkinson’s disease-associated LRRK2.
Dederer, V., Sanz Murillo, M., Karasmanis, E. P., Hatch, K. S., Chatterjee, D., Preuss, F., Abdul Azeez, K. R., Nguyen, L. V., Galicia, C., Dreier, B., Plückthun, A., Versees, W., Mathea, S., Leschziner, A. E., Reck-Peterson, S. L., & Knapp, S. (2024).
Journal of Biological Chemistry, 300(7), 107469. https://doi.org/10.1016/j.jbc.2024.107469

 

Secreted Cytokines from Inflammatory Macrophages Modulate Sex Differences in Valvular Interstitial Cells on Hydrogel Biomaterials.
Félix Vélez, N. E., Tu, K., Guo, P., Reeves, R. R., & Aguado, B. A. (2024).
https://doi.org/10.1101/2024.11.15.623805

 

Far-Red Chemigenetic Biosensors for Multi-Dimensional and Super-Resolved Kinase Activity Imaging.
Frei, M. S., Sanchez, S. A., Liu, L., Schneider, F., Wang, Z., Hakozaki, H., Li, Y., Lyons, A. C., Rohm, T. V., Olefsky, J. M., Shi, L., Schöneberg, J., Fraser, S. E., Mehta, S., Wang, Y., & Zhang, J. (2024). https://doi.org/10.1101/2024.02.10.579766

Y Chromosome Linked Uty Modulates Sex Differences in Valvular Fibroblast Methylation in Response to Nanoscale Extracellular Matrix Cues.
Gorashi, R. M., Baddour, T., Chittle, S. J., Vélez, N. E., Wenning, M. A., Anseth, K. S., Mestroni, L., Peña, B., Guo, P., & Aguado, B. A. (2024).
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Molecular determinants and signaling effects of PKA riα phase separation
Hardy, J. C., Pool, E. H., Bruystens, J. G. H., Zhou, X., Li, Q., Zhou, D. R., Palay, M., Tan, G., Chen, L., Choi, J.
L. C., Lee, H. N., Strack, S., Wang, D., Taylor, S. S., Mehta, S., & Zhang, J.
Molecular Cell, 84(8). https://doi.org/10.1016/j.molcel.2024.03.002

Mitochondrial protein heterogeneity stems from the stochastic nature of co-translational protein targeting in cell senescence.
Khan, A. H., Gu, X., Patel, R. J., Chuphal, P., Viana, M. P., Brown, A. I., Zid, B. M., & Tsuboi, T. (2024). 
Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-52183-y

RTN3L and Calcoco1 function in parallel to maintain proteostasis in the endoplasmic reticulum.
Kumar, K., Chidambaram, R., Parashar, S., & Ferro-Novick, S.
Autophagy, 1–9. https://doi.org/10.1080/15548627.2024.2353502

Cyclin B3 is a dominant fast-acting cyclin that drives rapid early embryonic mitoses.
Lara-Gonzalez, P., Variyar, S., Moghareh, S., Nguyen, A. C., Kizhedathu, A., Budrewicz, J., Schlientz, A., Varshney, N., Bellaart, A., Oegema, K., Bardwell, L., & Desai, A. (2024). 
Journal of Cell Biology, 223(11). https://doi.org/10.1083/jcb.202308034

 

Defining the activity of pro-reparative extracellular vesicles in wound healing based on MIRNA payloads and cell type-specific lineage mapping.
Park, D. J., Choi, W., Sayeed, S., Dorschner, R. A., Rainaldi, J., Ho, K., Kezios, J., Nolan, J. P., Mali, P., Costantini, T., & Eliceiri, B. P.
Molecular Therapy. https://doi.org/10.1016/j.ymthe.2024.02.019

 Unraveling the mechanisms of vestibular neuron formation from human induced pluripotent stem cells.
Norton, B., Quirk, A., & Matsuoka, A. J. (2024). 
Tissue Engineering Part A, 30(3–4), 131–143. https://doi.org/10.1089/ten.tea.2023.0166

Engineered nanotopographies induce transient openings in the nuclear membrane.
Sarikhani, E., Patel, V., Li, Z., Meganathan, D. P., Rahmani, K., Sadr, L., Hosseini, R., Visda, D., Shukla, S., Naghsh‐Nilchi, H., Balaji, A., McMahon, G., Chen, S., Schöneberg, J., McHugh, C. A., Shi, L., & Jahed, Z. (2024).
Advanced Functional Materials. https://doi.org/10.1002/adfm.202410035

Emissive alkylated guanine analogs as probes for monitoring o6-alkylguanine-DNA-transferase activity.
Steinbuch, K. B., Bucardo, M., & Tor, Y.
ACS Omega. https://doi.org/10.1021/acsomega.4c05700

Emissive guanosine analog applicable for real-time live cell imaging.
Steinbuch, K. B., Cong, D., Rodriguez, A. J., & Tor, Y. 
ACS Chemical Biology, 19(8), 1836–1841. https://doi.org/10.1021/acschembio.4c00398

 Sensitive Fluorescent Biosensor Reveals Differential Subcellular Regulation of PKC.
Su, Q., Zhang, J., Lin, W., Zhang, J.-F., Newton, A. C., Mehta, S., Yang, J., & Zhang, J. (2024). https://doi.org/10.1101/2024.03.29.587373

Determining Sex Differences in Drug Combinations Targeting Aortic Valve Myofibroblast Activation Using an Artificial Intelligence Derived Platform.
Vogt, B. J., Wang, P., Chavez, M., Guo, P., Chow, E. K.-H., Ho, D., & Aguado, B. A. (2024).
https://doi.org/10.1101/2024.10.02.615251

Lung fibroblasts take up breast cancer cell-derived extracellular vesicles partially through MEK2-dependent macropinocytosis.
Wan, Y., Zhao, Y., Cao, M., Wang, J., Tran, S. V., Song, Z., Hsueh, B. W., & Wang, S. E. (2024).
Cancer Research Communications, 4(1), 170–181. https://doi.org/10.1158/2767-9764.crc-23-0316

Exoslonano: Multi-Modal Nanogold Tags for Identification of Macromolecules in Live Cells & Cryo-Electron Tomograms.
Young, L. N., Sherrard, A., Zhou, H., Shaikh, F., Hutchings, J., Riggi, M., Rosen, M. K., Giraldez, A. J., & Villa, E. (2024).
 https://doi.org/10.1101/2024.10.12.617288

A Transcriptionally Active Lipid Vesicle Encloses the InjectedChimalliviridaeGenome in Early Infection.
Armbruster, E. G., Rani, P., Lee, J., Klusch, N., Hutchings, J., Hoffman, L. Y., Buschkaemper, H., Enustun, E., Adler, B. A., Inlow, K., VanderWal, A. R., Hoffman, M. Y., Daksh, D., Aindow, A., Deep, A., Rodriguez, Z. K., Morgan, C. J., Ghassemian, M., Laughlin, T. G., … Pogliano, J. (2023).  https://doi.org/10.1101/2023.09.20.558163

Senataxin helicase, the causal gene defect in ALS4, is a significant modifier of c9orf72 als G4C2 and arginine-containing dipeptide repeat toxicity.
Bennett, C. L., Dastidar, S., Arnold, F. J., McKinstry, S. U., Stockford, C., Freibaum, B. D., Sopher, B. L., Wu, M., Seidner, G., Joiner, W., Taylor, J. P., West, R. J., & La Spada, A. R. (2023).
Acta Neuropathologica Communications, 11(1). https://doi.org/10.1186/s40478-023-01665-z

Heterozygous Mutations in SOX2 may cause Idiopathic Hypogonadotropic Hypogonadism via Dominant-negative Mechanisms
Cassin. J.,* Stamou, M. I.,* Keefe, K. W.,* Sung, K. E., Bojo, C. C., Tonsfeldt, K. J., Rojas, R. A., Ferreira Lopes, V., Plummer, L., Salnikov, K. B., Keefe Jr., D. L., Ozata, M., Genel, M., Georgopoulos, N. A., Hall, J. E., Crowley Jr., W. F., Seminara, S. B., Mellon, P. L., ^# Balasubramanian, R.^#
Journal of Clinical Investigation Insight 8(3):e164324. *Co-first authors. ^#Co-Senior authors. PMID: 36602867. PMC9977424.10.1172/jci.insight.164324

Electrical signals in the ER are cell type and stimulus specific with extreme spatial compartmentalization in neurons
Campbell, E. P., Abushawish, A. A., Valdez, L. A., Bell, M. K., Haryono, M., Rangamani, P., & Bloodgood, B. L. (2023).
Cell Reports, 42(1), 111943. https://doi.org/10.1016/j.celrep.2022.111943

 Infusible extracellular matrix biomaterial promotes vascular integrity and modulates the inflammatory response in acute traumatic brain injury.
Diaz, M. D., Kandell, R. M., Wu, J. R., Chen, A., Christman, K. L., & Kwon, E. J. (2023).
Advanced Healthcare Materials, 12(25). https://doi.org/10.1002/adhm.202300782

Re-examining the role of the dorsal fan-shaped body in promoting sleep in drosophila
De, J., Wu, M., Lambatan, V., Hua, Y., & Joiner, W. J.
Current Biology, 33(17). https://doi.org/10.1016/j.cub.2023.07.043 

 Reversible phase separation of ESCRT protein alix through tyrosine phosphorylation.
Elias, R. D., Zhu, Y., Su, Q., Ghirlando, R., Zhang, J., & Deshmukh, L.
Science Advances, 9(28). https://doi.org/10.1126/sciadv.adg3913

SALL1 enforces microglia-specific DNA binding and function of Smads to establish microglia identity.
Fixsen, B. R., Han, C. Z., Zhou, Y., Spann, N. J., Saisan, P., Shen, Z., Balak, C., Sakai, M., Cobo, I., Holtman, I. R., Warden, A. S., Ramirez, G., Collier, J. G., Pasillas, M. P., Yu, M., Hu, R., Li, B., Belhocine, S., Gosselin, D., … Glass, C. K.
Nature Immunology, 24(7), 1188–1199. https://doi.org/10.1038/s41590-023-01528-8

 

Human microglia maturation is underpinned by specific gene regulatory networks Han, C. Z., Li, R. Z., Hansen, E., Trescott, S., Fixsen, B. R., Nguyen, C. T., Mora, C. M., Spann, N. J., Bennett, H. R., Poirion, O., Buchanan, J., Warden, A. S., Xia, B., Schlachetzki, J. C. M., Pasillas, M. P., Preissl, S., Wang, A., O’Connor, C., Shriram, S., … Coufal, N. G. (2023).
Immunity, 56(9). https://doi.org/10.1016/j.immuni.2023.07.016

Bub-1-bound PLK-1 directs CDC-20 kinetochore recruitment to ensure timely embryonic mitoses. Houston, J., Ohta, M., Gómez-Cavazos, J. S., Deep, A., Corbett, K. D., Oegema, K., Lara-Gonzalez, P., Kim, T., & Desai, A. (2023).
Current Biology, 33(11). https://doi.org/10.1016/j.cub.2023.04.021

LIS1 relieves cytoplasmic dynein-1 autoinhibition by acting as a molecular wedge
Karasmanis, E. P., Reimer, J. M., Kendrick, A. A., Nguyen, K. H., Rodriguez, J. A., Truong, J. B., Lahiri, I., Reck-Peterson, S. L., & Leschziner, A. E. (2023). 
Nature Structural & Molecular Biology, 30(9), 1357–1364. https://doi.org/10.1038/s41594-023-01069-6

 

LIS1 slows force-induced detachment of cytoplasmic dynein from microtubules.

The anaphase-promoting complex controls a ubiquitination-phosphoprotein axis in chromatin during neurodevelopment
Ledvin, L., Gassaway, B. M., Tawil, J., Urso, O., Pizzo, D., Welsh, K. A., Bolhuis, D. L., Fisher, D., Bonni, A., Gygi, S. P., Brown, N. G., & Ferguson, C. J.
Developmental Cell, 58(23). https://doi.org/10.1016/j.devcel.2023.10.002

The Lung Employs an Intrinsic Surfactant-Mediated Inflammatory Response for Viral Defense
Leibel, S. L., McVicar, R. N., Murad, R., Kwong, E. M., Clark, A. E., Alvarado, A., Grimmig, B. A., Nuryyev, R., Young, R. E., Lee, J. C., Peng, W., Zhu, Y. P., Griffis, E., Nowell, C. J., Liu, K., James, B., Alarcon, S., Malhotra, A., Gearing, L. J., … Snyder, E. Y.
Biorxiv  https://doi.org/10.1101/2023.01.26.525578

Exploring the consequences of redirecting an exocytic rab onto endocytic vesicles.
Li, X., Liu, D., Griffis, E., & Novick, P. (2023).
Molecular Biology of the Cell, 34(5). https://doi.org/10.1091/mbc.e23-01-0037

Cortical polarity ensures its own asymmetric inheritance in the stomatal lineage to pattern the leaf surface.
Muroyama, A., Gong, Y., Hartman, K. S., & Bergmann, D. C. (2023).
Science, 381(6653), 54–59. https://doi.org/10.1126/science.add6162

Kinetochore dynein is sufficient to biorient chromosomes and remodel the outer kinetochore
Prevo B, Cheerambathur DK, Earnshaw WC, Desai A.
BioRxiv .  doi: 10.1101/2023.03.23.534015.

Avidity-based method for the efficient generation of monoubiquitinated recombinant proteins
Nelson, S. L., Li, Y., Chen, Y., & Deshmukh, L. 
Journal of the American Chemical Society, 145(14), 7748–7752. https://doi.org/10.1021/jacs.3c01943

RNA recoding in cephalopods tailors microtubule motor protein function
Rangan, K. J., & Reck-Peterson, S. L. (2023).
Cell, 186(12). https://doi.org/10.1016/j.cell.2023.04.032

Structure of LRRK1 and mechanisms of autoinhibition and activation
Reimer, J. M., Dickey, A. M., Lin, Y. X., Abrisch, R. G., Mathea, S., Chatterjee, D., Fay, E. J., Knapp, S., Daugherty, M. D., Reck-Peterson, S. L., & Leschziner, A. E. (2023).
Nature Structural & Molecular Biology, 30(11), 1735–1745. https://doi.org/10.1038/s41594-023-01109-1

Dermomyotome-derived endothelial cells migrate to the dorsal aorta to support hematopoietic stem cell emergence.
Sahai-Hernandez, P., Pouget, C., Eyal, S., Svoboda, O., Chacon, J., Grimm, L., Gjøen, T., & Traver, D. (2023). 
eLife, 12. https://doi.org/10.7554/elife.58300

Engineering Cell and Nuclear Morphology on Nano Topography by Contact-Free Protein Micropatterning
Sarikhani, E., Meganathan, D. P., Rahmani, K., Tsai, C.-T., Marquez-Serrano, A., Li, X., Santoro, F., Cui, B., Klausen, L. H., & Jahed, Z.
Engineering Cell and Nuclear Morphology on Nano Topography by Contact-Free Protein Micropatterning. https://doi.org/10.1101/2023.06.05.543791
 
ALS variants of annexin A11’s proline-rich domain impair its S100A6-mediated fibril dissolution.
Shihora, A., Elias, R. D., Hammond, J. A., Ghirlando, R., & Deshmukh, L.
ACS Chemical Neuroscience, 14(15), 2583–2589. https://doi.org/10.1021/acschemneuro.3c00169
 
The dual-function chemokine receptor CCR2 drives migration and chemokine scavenging through distinct mechanisms.
Shroka, T. M., Kufareva, I., Salanga, C. L., & Handel, T. M.
Science Signaling, 16(770). https://doi.org/10.1126/scisignal.abo4314

Woronin body hitchhiking on early endosomes is dispensable for septal localization in aspergillus nidulans
Songster, L. D., Bhuyan, D., Christensen, J. R., & Reck-Peterson, S. L. (2023).
Molecular Biology of the Cell, 34(7). https://doi.org/10.1091/mbc.e23-01-0025

The Transcription Factor VAX1 in VIP Neurons of the Suprachiasmatic Nucleus Impacts Circadian RhythmGeneration, Depressive-like Behavior, and the Reproductive Axis in a Sex-specific Manner in Mice
Van Loh, B. M.,^* Yaw, A. M.,^* Breuer, J. A., Jackson, B., Nguyen, D., Jang, K., Ramos, F., Ho, E. V., Cui, L. J., Gillette, D. L. M., Sempere, L., Gorman, M. R., Tonsfeldt, K. J., Mellon, P. L., Hoffmann, H. M.
Frontiers in Endocrinology 14:1269672. *Co-first authors. PMID: 38205198. PMC10777845.10.3389/fendo.2023.1269672

Functional Organization of Glycolytic Metabolon on Mitochondria
Wang, H., Vant, J., Wu, Y., Sánchez, R., Micou, M. L., Zhang, A., Luczak, V., Yu, S. B., Jabbo, M., Yoon, S.,
Abushawish, A. A., Ghassemian, M., Griffis, E., Hammarlund, M., Singharoy, A., & Pekkurnaz, G.
Biorxiv https://doi.org/10.1101/2023.08.26.554955

CTLA4 depletes T cell endogenous and trogocytosed B7 ligands via cis-endocytosis.
Xu, X., Dennett, P., Zhang, J., Sherrard, A., Zhao, Y., Masubuchi, T., Bui, J. D., Chen, X., & Hui, E. (2023).
Journal of Experimental Medicine, 220(7). https://doi.org/10.1084/jem.20221391
 
Phase separation and fibrillization of human annexin A7 are mediated by its proline-rich domain.
Yu, C., Nelson, S. L., Meisl, G., Ghirlando, R., & Deshmukh, L.
Biochemistry, 62(21), 3036–3040. https://doi.org/10.1021/acs.biochem.3c00349

Cis-B7:CD28 interactions at invaginated synaptic membranes provide CD28 co-stimulation and promote CD8+ T cell function and anti-tumor immunity.
Zhao, Y., Caron, C., Chan, Y.-Y., Lee, C. K., Xu, X., Zhang, J., Masubuchi, T., Wu, C., Bui, J. D., & Hui, E. (2023).
 Immunity, 56(6). https://doi.org/10.1016/j.immuni.2023.04.005

Net formation is a default epigenetic program controlled by PAD4 in apoptotic neutrophils
Zhu, Y. P., Speir, M., Tan, Z., Lee, J. C., Nowell, C. J., Chen, A. A., Amatullah, H., Salinger, A. J., Huang, C. J., Wu, G., Peng, W., Askari, K., Griffis, E., Ghassemian, M., Santini, J., Gerlic, M., Kiosses, W. B., Catz, S. D., Hoffman, H. M., … Croker, B. A.
Science Advances, 9(51). https://doi.org/10.1126/sciadv.adj1397

Mechanistic convergence of the TIGIT and PD-1 inhibitory pathways necessitates co-blockade to optimize anti-tumor CD8+ T cell responses.
Banta, K. L., Xu, X., Chitre, A. S., Au-Yeung, A., Takahashi, C., O’Gorman, W. E., Wu, T. D., Mittman, S., Cubas, R., Comps-Agrar, L., Fulzele, A., Bennett, E. J., Grogan, J. L., Hui, E., Chiang, E. Y., & Mellman, I. (2022).  
Immunity, 55(3). https://doi.org/10.1016/j.immuni.2022.02.005

Injury-induced pulmonary tuft cells are heterogenous, arise independent of key type 2 cytokines, and are dispensable for dysplastic repair.
Barr, J., Gentile, M. E., Lee, S., Kotas, M. E., Fernanda de Mello Costa, M., Holcomb, N. P., Jaquish, A., Palashikar, G., Soewignjo, M., McDaniel, M., Matsumoto, I., Margolskee, R., Von Moltke, J., Cohen, N. A., Sun, X., & Vaughan, A. E. (2022).
 eLife, 11. https://doi.org/10.7554/elife.78074 

An erad‐independent role for Rhomboid pseudoprotease DFM1 in mediating sphingolipid homeostasis. 
Bhaduri, S., Aguayo, A., Ohno, Y., Proietto, M., Jung, J., Wang, I., Kandel, R., Singh, N., Ibrahim, I., Fulzele, A., Bennett, E. J., Kihara, A., & Neal, S. E. (2022).
The EMBO Journal, 42(4). https://doi.org/10.15252/embj.2022112275

INF2-mediated actin filament reorganization confers intrinsic resilience to neuronal ischemic injury.
Calabrese, B., Jones, S. L., Shiraishi-Yamaguchi, Y., Lingelbach, M., Manor, U., Svitkina, T. M., Higgs, H. N., Shih, A. Y., & Halpain, S.
Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-33268-y

Progression of the pluripotent epiblast depends upon the NMD factor UPF2
Chousal, J. N., Sohni, A., Vitting-Seerup, K., Cho, K., Kim, M., Tan, K., Porse, B., Wilkinson, M. F., & Cook-Andersen, H. (2022).
Development, 149(21). https://doi.org/10.1242/dev.200764

1-deoxysphingolipid synthesis compromises Anchorage-independent growth and plasma membrane endocytosis in cancer cells.
Cordes, T., Kuna, R. S., McGregor, G. H., Khare, S. V., Gengatharan, J., Muthusamy, T., & Metallo, C. M. (2022).
Journal of Lipid Research, 63(10), 100281. https://doi.org/10.1016/j.jlr.2022.100281

Structural basis for cytoplasmic dynein-1 regulation by LIS1
Gillies, J. P., Reimer, J. M., Karasmanis, E. P., Lahiri, I., Htet, Z. M., Leschziner, A. E., & Reck-Peterson, S. L. (2022).
eLife, 11. https://doi.org/10.7554/elife.71229

Mel-28/Elys and CENP-C coordinately control Outer Kinetochore assembly and meiotic chromosome-microtubule interactions
Hattersley, N., Schlientz, A. J., Prevo, B., Oegema, K., & Desai, A. (2022).
Current Biology, 32(11). https://doi.org/10.1016/j.cub.2022.04.046

Lis1 Binding Regulates Force-Induced Detachment of Cytoplasmic Dynein from Microtubules.
Kusakci, E., Htet, Z. M., Zhao, Y., Gillies, J. P., Reck-Peterson, S. L., & Yildiz, A. (2022a). 
https://doi.org/10.1101/2022.06.02.494578

Non-canonical β-adrenergic activation of ERK at endosomes.
Kwon, Y., Mehta, S., Clark, M., Walters, G., Zhong, Y., Lee, H. N., Sunahara, R. K., & Zhang, J. (2022).
Nature, 611(7934), 173–179. https://doi.org/10.1038/s41586-022-05343-3

Deletion of the Homeodomain Gene SIX3 from Kisspeptin Neurons Causes Subfertility in Female Mice
Lavalle, S. N., Chou, T., Hernandez, J., Naing, N. C. P., He, M. Y., Tonsfeldt, K. J., and Mellon, P. L.
Molecular and Cellular Endocrinology 456(4), 111577. PMID: 35121076. PMC8934285. doi: 10.1016/j.mce.2022.111577

Er-phagy requires the assembly of actin at sites of contact between the cortical ER and endocytic pits.
Liu, D., Mari, M., Li, X., Reggiori, F., Ferro-Novick, S., & Novick, P. (2022).  
Proceedings of the National Academy of Sciences, 119(6). https://doi.org/10.1073/pnas.2117554119

Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition
Lu, S., Hu, J., Arogundade, O. A., Goginashvili, A., Vazquez-Sanchez, S., Diedrich, J. K., Gu, J., Blum, J., Oung, S., Ye, Q., Yu, H., Ravits, J., Liu, C., Yates, J. R., & Cleveland, D. W. (2022).
Nature Cell Biology, 24(9), 1378–1393. https://doi.org/10.1038/s41556-022-00988-8

Control of Cell Proliferation by Memories of Mitosis
Meitinger, F., Davis, R. L., Martinez, M. B., Shiau, A. K., Oegema, K., & Desai, A. (2022). 
Biorxiv, https://doi.org/10.1101/2022.11.14.515741

Prions induce an early arc response and a subsequent reduction in mglur5 in the hippocampus
Ojeda-Juárez, D., Lawrence, J. A., Soldau, K., Pizzo, D. P., Wheeler, E., Aguilar-Calvo, P., Khuu, H., Chen, J., Malik, A., Funk, G., Nam, P., Sanchez, H., Geschwind, M. D., Wu, C., Yeo, G. W., Chen, X., Patrick, G. N., & Sigurdson, C. J.
Neurobiology of Disease, 172, 105834. https://doi.org/10.1016/j.nbd.2022.105834

Engineering inducible biomolecular assemblies for genome imaging and manipulation in living cells.
Peng, Q., Huang, Z., Sun, K., Liu, Y., Yoon, C. W., Harrison, R. E., Schmitt, D. L., Zhu, L., Wu, Y., Tasan, I., Zhao, H., Zhang, J., Zhong, S., Chien, S., & Wang, Y. (2022). 
Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-35504-x

Growth cone macropinocytosis of neurotrophin receptor and neuritogenesis are regulated by neuron navigator 1
Powers, R. M., Daza, R., Koehler, A. E., Courchet, J., Calabrese, B., Hevner, R. F., & Halpain, S. (2022).  Molecular Biology of the Cell, 33(7). https://doi.org/10.1091/mbc.e21-12-0623

 

Nuclear-enriched protein phosphatase 4 ensures outer kinetochore assembly prior to nuclear dissolution
Rocha, H., Simões, P. A., Budrewicz, J., Lara-Gonzalez, P., Carvalho, A. X., Dumont, J., Desai, A., & Gassmann, R. (2023).
Journal of Cell Biology, 222(3). https://doi.org/10.1083/jcb.202208154

Structural basis for parkinson’s disease-linked LRRK2’s binding to microtubules
Snead, D. M., Matyszewski, M., Dickey, A. M., Lin, Y. X., Leschziner, A. E., & Reck-Peterson, S. L. (2022).
Nature Structural & Molecular Biology, 29(12), 1196–1207. https://doi.org/10.1038/s41594-022-00863-y

Inputs to the sleep homeostat originate outside the brain
Satterfield, L. K., De, J., Wu, M., Qiu, T., & Joiner, W. J.
The Journal of Neuroscience, 42(29), 5695–5704. https://doi.org/10.1523/jneurosci.2113-21.2022

Antiviral function and viral antagonism of the rapidly evolving dynein activating Adaptor NINL
Stevens, D. A., Beierschmitt, C., Mahesula, S., Corley, M. R., Salogiannis, J., Tsu, B. V., Cao, B., Ryan, A. P., Hakozawki, H., Reck-Peterson, S. L., & Daugherty, M. D.
eLife, 11. https://doi.org/10.7554/elife.81606

Inferring cell communication using single-cell calcium spatiotemporal dynamics.
Taghdiri, N., & King, K. R. (2022).
STAR Protocols, 3(3), 101647. https://doi.org/10.1016/j.xpro.2022.101647

Female Fertility Does Not Require Bmal1 in Suprachiasmatic Nucleus Neurons Expressing Arginine Vasopressin, Vasoactive Intestinal Peptide, or Neuromedin-S
Tonsfeldt, K. J., Cui, L. J., Lee, J., Walbeek, T. J., Brusman, L. E., Jin, Y., Mieda, M., Gorman, M. R., Mellon, P. L.
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Inflammatory serum factors from aortic valve stenosis patients modulate sex differences in valvular myofibroblast activation and osteoblast-like differentiation
Vogt, B. J., Peters, D. K., Anseth, K. S., & Aguado, B. A. (2022).
Biomaterials Science, 10(22), 6341–6353. https://doi.org/10.1039/d2bm00844k

Cytoplasmic dynein-1 cargo diversity is mediated by the Combinatorial Assembly of FTS–hook–FHIP complexes
Christensen, J. R., Kendrick, A. A., Truong, J. B., Aguilar-Maldonado, A., Adani, V., Dzieciatkowska, M., & Reck-Peterson, S. L. (2021).
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The N-terminal tail of C. elegans CENP-a interacts with KNL-2 and is essential for centromeric chromatin assembly
de Groot, C., Houston, J., Davis, B., Gerson-Gurwitz, A., Monen, J., Lara-Gonzalez, P., Oegema, K., Shiau, A. K., & Desai, A. (2021).
Molecular Biology of the Cell, 32(12), 1193–1201. https://doi.org/10.1091/mbc.e20-12-0798

A FZD7-specific antibody–drug conjugate induces ovarian tumor regression in preclinical models.
Do, M., Wu, C. C. N., Sonavane, P. R., Juarez, E. F., Adams, S. R., Ross, J., Rodriguez y Baena, A., Patel, C., Mesirov, J. P., Carson, D. A., Advani, S. J., & Willert, K. (2021). 
Molecular Cancer Therapeutics, 21(1), 113–124. https://doi.org/10.1158/1535-7163.mct-21-0548

Reproductive Deficits Induced by Prenatal Anti-Mullerian Hormone Exposure Require Androgen Receptor in Kisspeptin Cells
Ho, E. V., Shi, C., Cassin, J., He, M. Y., Nguyen, R. D., Ryan, G. E., Tonsfeldt, K. J., and Mellon, P. L. 
Endocrinology 162(12), 1-23. PMID: 34529765. PMC8507963. doi: 10.1210/endocr/bqab197

The Transcription Factors SIX3 and VAX1 are Required for Suprachiasmatic Nucleus Circadian Output and Fertility in Female Mice
Hoffmann, H. M., Meadows, J. D., Breuer, J. A., Yaw, A. M., Nguyen, D., Tonsfeldt, K. J., Chin, A. Y., Devries, B. M., Trang, C., Oosterhouse, H. J., Lee, J. S., Doser, J. W., Gorman, M. R., Welsh, D. K., and Mellon, P. L.
Journal of Neuroscience Research99(10), 2625-2645. PMID: 34212416. PMC8577618.  doi: 10.1002/jnr.24864

Neuroendocrine basis for disrupted ovarian cyclicity in female mice during chronic undernutrition
Kreisman, M. J., Tadrousse, K. S., McCosh, R. B., & Breen, K. M.
Endocrinology, 162(8). https://doi.org/10.1210/endocr/bqab103

 Atf6 is essential for human cone photoreceptor development.
Kroeger, H., Grandjean, J. M., Chiang, W.-C. J., Bindels, D. D., Mastey, R., Okalova, J., Nguyen, A., Powers, E. T., Kelly, J. W., Grimsey, N. J., Michaelides, M., Carroll, J., Wiseman, R. L., & Lin, J. H. (2021). Proceedings of the National Academy of Sciences, 118(39). https://doi.org/10.1073/pnas.2103196118

Kiss1 is Differentially Regulated in Male and Female Mice by the Homeodomain Transcription Factor VAX1
Lavalle, S. N., Chou, T., Hernandez, J., Naing, N. C. P., Tonsfeldt, K. J., Hoffmann, H. M., and Mellon, P. L.
Molecular Cellular Endocrinology 534(8), 111358. PMID: 34098016. PMC8319105. doi: 10.1016/j.mce.2021.111358

The SARS-COV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein
Lu, S., Ye, Q., Singh, D., Cao, Y., Diedrich, J. K., Yates, J. R., Villa, E., Cleveland, D. W., & Corbett, K. D. (2021).
Nature Communications, 12(1). https://doi.org/10.1038/s41467-020-20768-y

 Persistent mrna localization defects and cell death in als neurons caused by transient cellular stress. 
Markmiller, S., Sathe, S., Server, K. L., Nguyen, T. B., Fulzele, A., Cody, N., Javaherian, A., Broski, S., Finkbeiner, S., Bennett, E. J., Lécuyer, E., & Yeo, G. W. (2021).
Cell Reports, 36(10), 109685. https://doi.org/10.1016/j.celrep.2021.109685
 

Optimizing microtubule arrangements for rapid cargo capture
Mogre, S. S., Christensen, J. R., Reck-Peterson, S. L., & Koslover, E. F. (2021).
Biophysical Journal, 120(22), 4918–4931. https://doi.org/10.1016/j.bpj.2021.10.020

 

Multi-clonal SARS-COV-2 neutralization by antibodies isolated from severe COVID-19 convalescent donors
Mor, M., Werbner, M., Alter, J., Safra, M., Chomsky, E., Lee, J. C., Hada-Neeman, S., Polonsky, K., Nowell, C. J., Clark, A. E., Roitburd-Berman, A., Ben-Shalom, N., Navon, M., Rafael, D., Sharim, H., Kiner, E., Griffis, E. R., Gershoni, J. M., Kobiler, O., … Freund, N. T.
PLOS Pathogens, 17(2). https://doi.org/10.1371/journal.ppat.1009165

Polo-like kinase 1 independently controls microtubule-nucleating capacity and size of the centrosome.
Ohta, M., Zhao, Z., Wu, D., Wang, S., Harrison, J. L., Gómez-Cavazos, J. S., Desai, A., & Oegema, K. F. (2021).
Journal of Cell Biology, 220(2). https://doi.org/10.1083/jcb.202009083

Endoplasmic reticulum tubules limit the size of misfolded protein condensates
Parashar, S., Chidambaram, R., Chen, S., Liem, C. R., Griffis, E., Lambert, G. G., Shaner, N. C., Wortham, M., Hay, J. C., & Ferro-Novick, S.
eLife, 10. https://doi.org/10.7554/elife.71642

 

PxdA interacts with the DIPA phosphatase to regulate peroxisome hitchhiking on early endosomes
Salogiannis, J., Christensen, J. R., Songster, L. D., Aguilar-Maldonado, A., Shukla, N., & Reck-Peterson, S. L. (2021).
Molecular Biology of the Cell, 32(6), 492–503. https://doi.org/10.1091/mbc.e20-08-0559

Cell Reports Methods, 1(8), 100132. https://doi.org/10.1016/j.crmeth.2021.100132 

Self-repair protects microtubules from destruction by molecular motors.
Triclin, S., Inoue, D., Gaillard, J., Htet, Z. M., DeSantis, M. E., Portran, D., Derivery, E., Aumeier, C., Schaedel, L., John, K., Leterrier, C., Reck-Peterson, S. L., Blanchoin, L., & Théry, M. (2021).
Nature Materials, 20(6), 883–891. https://doi.org/10.1038/s41563-020-00905-0

 Unbalanced regulation of α7 Nachrs by LY6H and Nacho contributes to neurotoxicity in alzheimer’s disease.
Wu, M., Liu, C. Z., Barrall, E. A., Rissman, R. A., & Joiner, W. J. (2021). 
The Journal of Neuroscience, 41(41), 8461–8474. https://doi.org/10.1523/jneurosci.0494-21.2021

Mouse model of experimental pulmonary hypertension: Lung Angiogram and right heart catheterization.
Xiong, M., Jain, P. P., Chen, J., Babicheva, A., Zhao, T., Alotaibi, M., Kim, N. H., Lai, N., Izadi, A., Rodriguez, M., Li, J., Balistrieri, A., Balistrieri, F., Parmisano, S., Sun, X., Valdez‐Jasso, D., Shyy, J. Y., Thistlethwaite, P. A., Wang, J., … Yuan, J. X. ‐J. (2021). 
Pulmonary Circulation, 11(4), 1–17. https://doi.org/10.1177/20458940211041512

Hsp70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells.
Yu, H., Lu, S., Gasior, K., Singh, D., Vazquez-Sanchez, S., Tapia, O., Toprani, D., Beccari, M. S., Yates, J. R., Da Cruz, S., Newby, J. M., Lafarga, M., Gladfelter, A. S., Villa, E., & Cleveland, D. W. (2021).
Science, 371(6529). https://doi.org/10.1126/science.abb4309

Immune response to intravenous immunoglobulin in patients with Kawasaki disease and MIS-C
Zhu, Yanfang P., Shamie, I., Lee, J. C., Nowell, C. J., Peng, W., Angulo, S., Le, L. N. N., Liu, Y., Miao, H., Xiong, H., Pena, C. J., Moreno, E., Griffis, E., Labou, S. G., Franco, A., Broderick, L., Hoffman, H. M., Shimizu, C., Lewis, N. E., … Croker, B. A.
Journal of Clinical Investigation, 131(20). https://doi.org/10.1172/jci147076

Conserved metabolite regulation of stress granule assembly via AdoMet
Kyle Begovich, Anthony Q. Vu, Gene Yeo and James E. Wilhelm
J. Cell Biol.  2020; 219, 8: e201904141. doi: 10.1083/jcb.201904141

The DAISHO peptides mediate drosophila defense against a subset of filamentous fungi.
Cohen, L. B., Lindsay, S. A., Xu, Y., Lin, S. J., & Wasserman, S. A. (2020).
Frontiers in Immunology, 11. https://doi.org/10.3389/fimmu.2020.00009

Structure of LRRK2 in Parkinson’s disease and model for microtubule interaction
C. K. Deniston, John Salogiannis, Sebastian Mathea, David. M. Snead, Indrajit Lahiri, Mariusz Matyszewski, Oscar Donosa, Reika Watanabe, Jan Böhning, Andrew K. Shiau, Stefan Knapp, Elizabeth Villa, Samara L. Reck-Peterson and Andres E. Leschziner
Nature. 2020; doi: 10.1038/s41586-020-2673-2

A non-canonical BRCT-phosphopeptide recognition mechanism underlies RhoA activation in cytokinesis
Gómez-Cavazos, J. S., Lee, K.-Y., Lara-González, P., Li, Y., Desai, A., Shiau, A. K., & Oegema, K. (2020).
Current Biology, 30(16). https://doi.org/10.1016/j.cub.2020.05.090

LIS1 promotes the formation of activated cytoplasmic dynein-1 complexes
Htet, Z. M., Gillies, J. P., Baker, R. W., Leschziner, A. E., DeSantis, M. E., & Reck-Peterson, S. L. (2020).
Nature Cell Biology, 22(5), 518–525. https://doi.org/10.1038/s41556-020-0506-z

RIα phase separation drives cAMP compartmentation and suppresses oncogenic signaling
Jason Z. Zhang, Tsan-Wen Lu, Lucas M. Stolerman, Brian Tenner, Jessica Yang, Jin-Fan Zhang, Martin Falcke, Padmini Rangamani, Susan S. Taylor, Sohum Mehta and Jin Zhang
Cell.  2020; 182, 16, 1531-1544,doi: 10.1016/j.cell.2020.07.043

Regulation of peroxisome and lipid droplet hitchhiking by PxdA and the DipA phosphatase
John Salogiannis, Jenna R. Christensen, Adriana Aguilar-Maldonado, Nandini Shukla, and Samara L. Reck-Peterson
bioRxiv. 2020; doi: 10.1101/2020.02.03.932616

Peripheral interleukin-1β inhibits arcuate kiss1 cells and LH pulses in female mice
Makowski, K. N., Kreisman, M. J., McCosh, R. B., Raad, A. A., & Breen, K. M. (2020).
Journal of Endocrinology, 246(2), 149–160. https://doi.org/10.1530/joe-20-0165

Hitching a ride: Mechanics of transport initiation through linker-mediated hitchhiking
Mogre, S. S., Christensen, J. R., Niman, C. S., Reck-Peterson, S. L., & Koslover, E. F. (2020).
Biophysical Journal, 118(6), 1357–1369. https://doi.org/10.1016/j.bpj.2020.01.024

A rationally enhanced red fluorescent protein expands the utility of FRET biosensors
Gary C. H. Mo, Clara Posner, Erik A. Rodriguez, Tengqian Sun and Jin Zhang
Nature Commun. 2020; 11, 1848. doi: 10.1038/s41467-020-15687-x

Spatially compartmentalized phase regulation of a Ca ²⁺-cAMP-PKA oscillatory circuit
Brian Tenner, Michael Getz, Brian Ross, Donya Ohadi, Christopher H. Bohrer, Eric Greenwald, Sohum Mehta, Jie Xiao, Padmini Rangamani and Jin Zhang
bioRxiv.  2020.01.10.902312.  doi: 10.1101/2020.01.10.902312

Mitochondrial volume fraction and translation duration impact mitochondrial mrna localization and protein synthesis.
Tsuboi, T., Viana, M. P., Xu, F., Yu, J., Chanchani, R., Arceo, X. G., Tutucci, E., Choi, J., Chen, Y. S., Singer, R. H., Rafelski, S. M., & Zid, B. M. (2020). 
eLife, 9. https://doi.org/10.7554/elife.57814

Pooled CRISPR screens with imaging on microraft arrays reveals stress granule-regulatory factors
Emily C. Wheeler, Anthony Q. Vu, Jaclyn M. Einstein, Matthew DiSalvo, Noorsher Ahmed, Eric L. Van Nostrand, Alexander A. Shishkin, Wenhao Jin, Nancy L. Allbritton and Gene W. Yeo
Nat. Methods. 2020; 17, 636-642, doi: 10.1038/s41592-020-0826-8

An ultrasensitive biosensor for high-resolution kinase activity imaging in awake mice.
Zhang, J.-F., Liu, B., Hong, I., Mo, A., Roth, R. H., Tenner, B., Lin, W., Zhang, J. Z., Molina, R. S., Drobizhev, M., Hughes, T. E., Tian, L., Huganir, R. L., Mehta, S., & Zhang, J. (2020). 
Nature Chemical Biology, 17(1), 39–46. https://doi.org/10.1038/s41589-020-00660-y

Phase separation of a PKA regulatory subunit controls camp compartmentation and oncogenic signaling.
Zhang, J. Z., Lu, T.-W., Stolerman, L. M., Tenner, B., Yang, J. R., Zhang, J.-F., Falcke, M., Rangamani, P., Taylor, S. S., Mehta, S., & Zhang, J. (2020).
Cell, 182(6). https://doi.org/10.1016/j.cell.2020.07.043

Tissue-specific macrophage responses to remote injury impact the outcome of subsequent local immune challenge.
Hoyer, F. F., Naxerova, K., Schloss, M. J., Hulsmans, M., Nair, A. V., Dutta, P., Calcagno, D. M., Herisson, F., Anzai, A., Sun, Y., Wojtkiewicz, G., Rohde, D., Frodermann, V., Vandoorne, K., Courties, G., Iwamoto, Y., Garris, C. S., Williams, D. L., Breton, S., … Nahrendorf, M. (2019). 
 Immunity, 51(5). https://doi.org/10.1016/j.immuni.2019.10.010

Hook3 is a scaffold for the opposite-polarity microtubule-based motors cytoplasmic dynein-1 and KIF1C
Agnieszka A. Kendrick, Andrea M. Dickey, William B. Redwine, Phuoc Tien Tran, Laura Pontano Vaites, Monika Dzieciatkowska, J. Wade Harper,  and Samara L. Reck-Peterson
J Cell Biol . 2019; 218 (9): 2982–3001. doi: 10.1083/jcb.201812170

Estradiol enables chronic corticosterone to inhibit pulsatile luteinizing hormone secretion and suppress KISS1 neuronal activation in female mice
Kreisman, M. J., McCosh, R. B., Tian, K., Song, C. I., & Breen, K. M. (2019).
Neuroendocrinology, 110(6), 501–516. https://doi.org/10.1159/000502978

 

Insulin‐induced hypoglycaemia suppresses pulsatile luteinising hormone secretion and arcuate Kiss1 cell activation in female mice
Richard B. McCosh, Michael J. Kreisman, Katherine Tian, Bryan S. Ho, Varykina G. Thackray, and Kellie M. Breen
J Neuroendocrinol.  2019;  31:e12813. doi: 10.1111/jne.12813

The G2-to-M transition is ensured by a dual mechanism that protects cyclin B from degradation by cdc20-activated APC/C
Lara-Gonzalez, P., Moyle, M. W., Budrewicz, J., Mendoza-Lopez, J., Oegema, K., & Desai, A. (2019).
Developmental Cell, 51(3). https://doi.org/10.1016/j.devcel.2019.09.005

Computational modeling reveals frequency modulation of calcium-camp/PKA pathway in dendritic spines. Ohadi, D., Schmitt, D. L., Calabrese, B., Halpain, S., Zhang, J., & Rangamani, P.
Biophysical Journal, 117(10), 1963–1980. https://doi.org/10.1016/j.bpj.2019.10.003