Botulinum Neurotoxin Induces Neurotoxic Microglia Mediated by Exogenous Inflammatory Responses
Ambrin, G., Kang, Y. J., Do, K. V., Lee, C., Signh, B. R., & Cho, H. 
Advanced Science, 2305326–2305326. https://doi.org/10.1002/advs.202305326

Molecular profiling of human blastocysts reveals primitive endoderm defects among embryos of decreased implantation potential
Chousal, J. N., Morey, R., Srinivasan, S., Lee, K., Zhang, W., Yeo, A. L., To, C., Cho, K., Garzo, V. G., Parast, M. M., Laurent, L. C., & Cook-Andersen, H.
Cell Reports, 43(2), 113701. https://doi.org/10.1016/j.celrep.2024.113701

Heterozygous Mutations in SOX2 may cause Idiopathic Hypogonadotropic Hypogonadism via Dominant-negative Mechanisms
Cassin. J.,* Stamou, M. I.,* Keefe, K. W.,* Sung, K. E., Bojo, C. C., Tonsfeldt, K. J., Rojas, R. A., Ferreira Lopes, V., Plummer, L., Salnikov, K. B., Keefe Jr., D. L., Ozata, M., Genel, M., Georgopoulos, N. A., Hall, J. E., Crowley Jr., W. F., Seminara, S. B., Mellon, P. L., ^# Balasubramanian, R.^#
Journal of Clinical Investigation Insight 8(3):e164324. *Co-first authors. ^#Co-Senior authors. PMID: 36602867. PMC9977424.10.1172/jci.insight.164324

Electrical signals in the ER are cell type and stimulus specific with extreme spatial compartmentalization in neurons
Campbell, E. P., Abushawish, A. A., Valdez, L. A., Bell, M. K., Haryono, M., Rangamani, P., & Bloodgood, B. L. (2023).
Cell Reports, 42(1), 111943. https://doi.org/10.1016/j.celrep.2022.111943

Re-examining the role of the dorsal fan-shaped body in promoting sleep in drosophila
De, J., Wu, M., Lambatan, V., Hua, Y., & Joiner, W. J.
Current Biology, 33(17). https://doi.org/10.1016/j.cub.2023.07.043

Human microglia maturation is underpinned by specific gene regulatory networks Han, C. Z., Li, R. Z., Hansen, E., Trescott, S., Fixsen, B. R., Nguyen, C. T., Mora, C. M., Spann, N. J., Bennett, H. R., Poirion, O., Buchanan, J., Warden, A. S., Xia, B., Schlachetzki, J. C. M., Pasillas, M. P., Preissl, S., Wang, A., O’Connor, C., Shriram, S., … Coufal, N. G. (2023).
Immunity, 56(9). https://doi.org/10.1016/j.immuni.2023.07.016

The anaphase-promoting complex controls a ubiquitination-phosphoprotein axis in chromatin during neurodevelopment
Ledvin, L., Gassaway, B. M., Tawil, J., Urso, O., Pizzo, D., Welsh, K. A., Bolhuis, D. L., Fisher, D., Bonni, A., Gygi, S. P., Brown, N. G., & Ferguson, C. J.
Developmental Cell, 58(23). https://doi.org/10.1016/j.devcel.2023.10.002

The Lung Employs an Intrinsic Surfactant-Mediated Inflammatory Response for Viral Defense
Leibel, S. L., McVicar, R. N., Murad, R., Kwong, E. M., Clark, A. E., Alvarado, A., Grimmig, B. A., Nuryyev, R., Young, R. E., Lee, J. C., Peng, W., Zhu, Y. P., Griffis, E., Nowell, C. J., Liu, K., James, B., Alarcon, S., Malhotra, A., Gearing, L. J., … Snyder, E. Y.
Biorxiv  https://doi.org/10.1101/2023.01.26.525578

Kinetochore dynein is sufficient to biorient chromosomes and remodel the outer kinetochore
Prevo B, Cheerambathur DK, Earnshaw WC, Desai A.
BioRxiv .  doi: 10.1101/2023.03.23.534015.

Avidity-based method for the efficient generation of monoubiquitinated recombinant proteins
Nelson, S. L., Li, Y., Chen, Y., & Deshmukh, L. 
Journal of the American Chemical Society, 145(14), 7748–7752. https://doi.org/10.1021/jacs.3c01943RNA recoding in cephalopods tailors microtubule motor protein function
Rangan, K. J., & Reck-Peterson, S. L. (2023).
Cell, 186(12). https://doi.org/10.1016/j.cell.2023.04.032

Structure of LRRK1 and mechanisms of autoinhibition and activation
Reimer, J. M., Dickey, A. M., Lin, Y. X., Abrisch, R. G., Mathea, S., Chatterjee, D., Fay, E. J., Knapp, S., Daugherty, M. D., Reck-Peterson, S. L., & Leschziner, A. E. (2023).
Nature Structural & Molecular Biology, 30(11), 1735–1745. https://doi.org/10.1038/s41594-023-01109-1

Engineering Cell and Nuclear Morphology on Nano Topography by Contact-Free Protein Micropatterning Sarikhani, E., Meganathan, D. P., Rahmani, K., Tsai, C.-T., Marquez-Serrano, A., Li, X., Santoro, F., Cui, B., Klausen, L. H., & Jahed, Z.
Engineering Cell and Nuclear Morphology on Nano Topography by Contact-Free Protein Micropatterning. https://doi.org/10.1101/2023.06.05.543791

Woronin body hitchhiking on early endosomes is dispensable for septal localization in aspergillus nidulans
Songster, L. D., Bhuyan, D., Christensen, J. R., & Reck-Peterson, S. L. (2023).
Molecular Biology of the Cell, 34(7). https://doi.org/10.1091/mbc.e23-01-0025

The Transcription Factor VAX1 in VIP Neurons of the Suprachiasmatic Nucleus Impacts Circadian RhythmGeneration, Depressive-like Behavior, and the Reproductive Axis in a Sex-specific Manner in Mice
Van Loh, B. M.,^* Yaw, A. M.,^* Breuer, J. A., Jackson, B., Nguyen, D., Jang, K., Ramos, F., Ho, E. V., Cui, L. J., Gillette, D. L. M., Sempere, L., Gorman, M. R., Tonsfeldt, K. J., Mellon, P. L., Hoffmann, H. M.
Frontiers in Endocrinology 14:1269672. *Co-first authors. PMID: 38205198. PMC10777845.10.3389/fendo.2023.1269672

Functional Organization of Glycolytic Metabolon on Mitochondria
Wang, H., Vant, J., Wu, Y., Sánchez, R., Micou, M. L., Zhang, A., Luczak, V., Yu, S. B., Jabbo, M., Yoon, S.,
Abushawish, A. A., Ghassemian, M., Griffis, E., Hammarlund, M., Singharoy, A., & Pekkurnaz, G.
Biorxiv https://doi.org/10.1101/2023.08.26.554955

Net formation is a default epigenetic program controlled by PAD4 in apoptotic neutrophils
Zhu, Y. P., Speir, M., Tan, Z., Lee, J. C., Nowell, C. J., Chen, A. A., Amatullah, H., Salinger, A. J., Huang, C. J., Wu, G., Peng, W., Askari, K., Griffis, E., Ghassemian, M., Santini, J., Gerlic, M., Kiosses, W. B., Catz, S. D., Hoffman, H. M., … Croker, B. A.
Science Advances, 9(51). https://doi.org/10.1126/sciadv.adj1397

Progression of the pluripotent epiblast depends upon the NMD factor UPF2

Chousal, J. N., Sohni, A., Vitting-Seerup, K., Cho, K., Kim, M., Tan, K., Porse, B., Wilkinson, M. F., & Cook-Andersen, H. (2022).

Development, 149(21). https://doi.org/10.1242/dev.200764

Structural basis for cytoplasmic dynein-1 regulation by LIS1
Gillies, J. P., Reimer, J. M., Karasmanis, E. P., Lahiri, I., Htet, Z. M., Leschziner, A. E., & Reck-Peterson, S. L. (2022).
eLife, 11. https://doi.org/10.7554/elife.71229

Mel-28/Elys and CENP-C coordinately control Outer Kinetochore assembly and meiotic chromosome-microtubule interactions

Hattersley, N., Schlientz, A. J., Prevo, B., Oegema, K., & Desai, A. (2022).

Current Biology, 32(11). https://doi.org/10.1016/j.cub.2022.04.046

Lis1 Binding Regulates Force-Induced Detachment of Cytoplasmic Dynein from Microtubules.

Kusakci, E., Htet, Z. M., Zhao, Y., Gillies, J. P., Reck-Peterson, S. L., & Yildiz, A. (2022a). 
https://doi.org/10.1101/2022.06.02.494578

Deletion of the Homeodomain Gene SIX3 from Kisspeptin Neurons Causes Subfertility in Female Mice
Lavalle, S. N., Chou, T., Hernandez, J., Naing, N. C. P., He, M. Y., Tonsfeldt, K. J., and Mellon, P. L.
Molecular and Cellular Endocrinology 456(4), 111577. PMID: 35121076. PMC8934285. doi: 10.1016/j.mce.2022.111577

Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition
Lu, S., Hu, J., Arogundade, O. A., Goginashvili, A., Vazquez-Sanchez, S., Diedrich, J. K., Gu, J., Blum, J., Oung, S., Ye, Q., Yu, H., Ravits, J., Liu, C., Yates, J. R., & Cleveland, D. W. (2022).
Nature Cell Biology, 24(9), 1378–1393. https://doi.org/10.1038/s41556-022-00988-8

Control of Cell Proliferation by Memories of Mitosis
Meitinger, F., Davis, R. L., Martinez, M. B., Shiau, A. K., Oegema, K., & Desai, A. (2022). 
Biorxiv, https://doi.org/10.1101/2022.11.14.515741

Prions induce an early arc response and a subsequent reduction in mglur5 in the hippocampus
Ojeda-Juárez, D., Lawrence, J. A., Soldau, K., Pizzo, D. P., Wheeler, E., Aguilar-Calvo, P., Khuu, H., Chen, J., Malik, A., Funk, G., Nam, P., Sanchez, H., Geschwind, M. D., Wu, C., Yeo, G. W., Chen, X., Patrick, G. N., & Sigurdson, C. J.
Neurobiology of Disease, 172, 105834. https://doi.org/10.1016/j.nbd.2022.105834

Nuclear-enriched protein phosphatase 4 ensures outer kinetochore assembly prior to nuclear dissolution
Rocha, H., Simões, P. A., Budrewicz, J., Lara-Gonzalez, P., Carvalho, A. X., Dumont, J., Desai, A., & Gassmann, R. (2023).
Journal of Cell Biology, 222(3). https://doi.org/10.1083/jcb.202208154

Structural basis for parkinson’s disease-linked LRRK2’s binding to microtubules
Snead, D. M., Matyszewski, M., Dickey, A. M., Lin, Y. X., Leschziner, A. E., & Reck-Peterson, S. L. (2022).
Nature Structural & Molecular Biology, 29(12), 1196–1207. https://doi.org/10.1038/s41594-022-00863-y

Inputs to the sleep homeostat originate outside the brain
Satterfield, L. K., De, J., Wu, M., Qiu, T., & Joiner, W. J.
The Journal of Neuroscience, 42(29), 5695–5704. https://doi.org/10.1523/jneurosci.2113-21.2022

Antiviral function and viral antagonism of the rapidly evolving dynein activating Adaptor NINL
Stevens, D. A., Beierschmitt, C., Mahesula, S., Corley, M. R., Salogiannis, J., Tsu, B. V., Cao, B., Ryan, A. P., Hakozawki, H., Reck-Peterson, S. L., & Daugherty, M. D.
eLife, 11. https://doi.org/10.7554/elife.81606

Female Fertility Does Not Require Bmal1 in Suprachiasmatic Nucleus Neurons Expressing Arginine Vasopressin, Vasoactive Intestinal Peptide, or Neuromedin-S
Tonsfeldt, K. J., Cui, L. J., Lee, J., Walbeek, T. J., Brusman, L. E., Jin, Y., Mieda, M., Gorman, M. R., Mellon, P. L.
Frontiers in Endocrinology 13:956169. PMID: 35992114. PMC9389073. doi: 10.3389/fendo.2022.956169

Cytoplasmic dynein-1 cargo diversity is mediated by the Combinatorial Assembly of FTS–hook–FHIP complexes
Christensen, J. R., Kendrick, A. A., Truong, J. B., Aguilar-Maldonado, A., Adani, V., Dzieciatkowska, M., & Reck-Peterson, S. L. (2021).
eLife, 10. https://doi.org/10.7554/elife.74538

The N-terminal tail of C. elegans CENP-a interacts with KNL-2 and is essential for centromeric chromatin assembly
de Groot, C., Houston, J., Davis, B., Gerson-Gurwitz, A., Monen, J., Lara-Gonzalez, P., Oegema, K., Shiau, A. K., & Desai, A. (2021).
Molecular Biology of the Cell, 32(12), 1193–1201. https://doi.org/10.1091/mbc.e20-12-0798

Reproductive Deficits Induced by Prenatal Anti-Mullerian Hormone Exposure Require Androgen Receptor in Kisspeptin Cells
Ho, E. V., Shi, C., Cassin, J., He, M. Y., Nguyen, R. D., Ryan, G. E., Tonsfeldt, K. J., and Mellon, P. L. 
Endocrinology 162(12), 1-23. PMID: 34529765. PMC8507963. doi: 10.1210/endocr/bqab197

The Transcription Factors SIX3 and VAX1 are Required for Suprachiasmatic Nucleus Circadian Output and Fertility in Female Mice
Hoffmann, H. M., Meadows, J. D., Breuer, J. A., Yaw, A. M., Nguyen, D., Tonsfeldt, K. J., Chin, A. Y., Devries, B. M., Trang, C., Oosterhouse, H. J., Lee, J. S., Doser, J. W., Gorman, M. R., Welsh, D. K., and Mellon, P. L.
Journal of Neuroscience Research99(10), 2625-2645. PMID: 34212416. PMC8577618.  doi: 10.1002/jnr.24864

Neuroendocrine basis for disrupted ovarian cyclicity in female mice during chronic undernutrition
Kreisman, M. J., Tadrousse, K. S., McCosh, R. B., & Breen, K. M.
Endocrinology, 162(8). https://doi.org/10.1210/endocr/bqab103

Kiss1 is Differentially Regulated in Male and Female Mice by the Homeodomain Transcription Factor VAX1
Lavalle, S. N., Chou, T., Hernandez, J., Naing, N. C. P., Tonsfeldt, K. J., Hoffmann, H. M., and Mellon, P. L.
Molecular Cellular Endocrinology 534(8), 111358. PMID: 34098016. PMC8319105. doi: 10.1016/j.mce.2021.111358

The SARS-COV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein
Lu, S., Ye, Q., Singh, D., Cao, Y., Diedrich, J. K., Yates, J. R., Villa, E., Cleveland, D. W., & Corbett, K. D. (2021).
Nature Communications, 12(1). https://doi.org/10.1038/s41467-020-20768-y

Optimizing microtubule arrangements for rapid cargo capture
Mogre, S. S., Christensen, J. R., Reck-Peterson, S. L., & Koslover, E. F. (2021).
Biophysical Journal, 120(22), 4918–4931. https://doi.org/10.1016/j.bpj.2021.10.020

Multi-clonal SARS-COV-2 neutralization by antibodies isolated from severe COVID-19 convalescent donors
Mor, M., Werbner, M., Alter, J., Safra, M., Chomsky, E., Lee, J. C., Hada-Neeman, S., Polonsky, K., Nowell, C. J., Clark, A. E., Roitburd-Berman, A., Ben-Shalom, N., Navon, M., Rafael, D., Sharim, H., Kiner, E., Griffis, E. R., Gershoni, J. M., Kobiler, O., … Freund, N. T.
PLOS Pathogens, 17(2). https://doi.org/10.1371/journal.ppat.1009165

PxdA interacts with the DIPA phosphatase to regulate peroxisome hitchhiking on early endosomes
Salogiannis, J., Christensen, J. R., Songster, L. D., Aguilar-Maldonado, A., Shukla, N., & Reck-Peterson, S. L. (2021).
Molecular Biology of the Cell, 32(6), 492–503. https://doi.org/10.1091/mbc.e20-08-0559

Self-repair protects microtubules from destruction by molecular motors.
Triclin, S., Inoue, D., Gaillard, J., Htet, Z. M., DeSantis, M. E., Portran, D., Derivery, E., Aumeier, C., Schaedel, L., John, K., Leterrier, C., Reck-Peterson, S. L., Blanchoin, L., & Théry, M. (2021).
Nature Materials, 20(6), 883–891. https://doi.org/10.1038/s41563-020-00905-0
Hsp70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells.
Yu, H., Lu, S., Gasior, K., Singh, D., Vazquez-Sanchez, S., Tapia, O., Toprani, D., Beccari, M. S., Yates, J. R., Da Cruz, S., Newby, J. M., Lafarga, M., Gladfelter, A. S., Villa, E., & Cleveland, D. W. (2021).
Science, 371(6529). https://doi.org/10.1126/science.abb4309

Immune response to intravenous immunoglobulin in patients with Kawasaki disease and MIS-C
Zhu, Yanfang P., Shamie, I., Lee, J. C., Nowell, C. J., Peng, W., Angulo, S., Le, L. N. N., Liu, Y., Miao, H., Xiong, H., Pena, C. J., Moreno, E., Griffis, E., Labou, S. G., Franco, A., Broderick, L., Hoffman, H. M., Shimizu, C., Lewis, N. E., … Croker, B. A.
Journal of Clinical Investigation, 131(20). https://doi.org/10.1172/jci147076

RIα phase separation drives cAMP compartmentation and suppresses oncogenic signaling
Jason Z. Zhang, Tsan-Wen Lu, Lucas M. Stolerman, Brian Tenner, Jessica Yang, Jin-Fan Zhang, Martin Falcke, Padmini Rangamani, Susan S. Taylor, Sohum Mehta and Jin Zhang
Cell.  2020; 182, 16, 1531-1544,doi: 10.1016/j.cell.2020.07.043

Hitching a ride: Mechanics of transport initiation through linker-mediated hitchhiking
Mogre, S. S., Christensen, J. R., Niman, C. S., Reck-Peterson, S. L., & Koslover, E. F. (2020).
Biophysical Journal, 118(6), 1357–1369. https://doi.org/10.1016/j.bpj.2020.01.024

Structure of LRRK2 in Parkinson’s disease and model for microtubule interaction
C. K. Deniston, John Salogiannis, Sebastian Mathea, David. M. Snead, Indrajit Lahiri, Mariusz Matyszewski, Oscar Donosa, Reika Watanabe, Jan Böhning, Andrew K. Shiau, Stefan Knapp, Elizabeth Villa, Samara L. Reck-Peterson and Andres E. Leschziner
Nature. 2020; doi: 10.1038/s41586-020-2673-2

 Hitching a ride: Mechanics of transport initiation through linker-mediated hitchhiking. Mogre, S. S., Christensen, J. R., Niman, C. S., Reck-Peterson, S. L., & Koslover, E. F. (2020).
Biophysical Journal, 118(6), 1357–1369. https://doi.org/10.1016/j.bpj.2020.01.024 

Regulation of peroxisome and lipid droplet hitchhiking by PxdA and the DipA phosphatase
John Salogiannis, Jenna R. Christensen, Adriana Aguilar-Maldonado, Nandini Shukla, and Samara L. Reck-Peterson
bioRxiv. 2020; doi: 10.1101/2020.02.03.932616

Conserved metabolite regulation of stress granule assembly via AdoMet
Kyle Begovich, Anthony Q. Vu, Gene Yeo and James E. Wilhelm
J. Cell Biol.  2020; 219, 8: e201904141. doi: 10.1083/jcb.201904141

Pooled CRISPR screens with imaging on microraft arrays reveals stress granule-regulatory factors
Emily C. Wheeler, Anthony Q. Vu, Jaclyn M. Einstein, Matthew DiSalvo, Noorsher Ahmed, Eric L. Van Nostrand, Alexander A. Shishkin, Wenhao Jin, Nancy L. Allbritton and Gene W. Yeo
Nat. Methods. 2020; 17, 636-642, doi: 10.1038/s41592-020-0826-8

Lis1 promotes the formation of maximally activated cytoplasmic dynein-1 complexes
Zaw Min Htet, John P. Gillies, Richard W. Baker, Andres E. Leschziner, Morgan E. DeSantis and Samara L. Reck-Peterson
Nat. Cell Biol. 2020; 5, 518-525. doi: 10.1038/s41556-020-0506-z

A rationally enhanced red fluorescent protein expands the utility of FRET biosensors
Gary C. H. Mo, Clara Posner, Erik A. Rodriguez, Tengqian Sun and Jin Zhang
Nature Commun. 2020; 11, 1848. doi: 10.1038/s41467-020-15687-x

The Daisho peptides mediate Drosophila defense against a subset of filamentous Fungi
Lianne B. Cohen, Scott A. Lindsay, Yangyang Xu, Samuel J. H. Lin and Steven A Wasserman
Front Immunol. 2020; 11, 1-9. doi: 10.3389/fimmu.2020.00009

Spatially compartmentalized phase regulation of a Ca ²⁺-cAMP-PKA oscillatory circuit
Brian Tenner, Michael Getz, Brian Ross, Donya Ohadi, Christopher H. Bohrer, Eric Greenwald, Sohum Mehta, Jie Xiao, Padmini Rangamani and Jin Zhang
bioRxiv.  2020.01.10.902312.  doi: 10.1101/2020.01.10.902312

Hook3 is a scaffold for the opposite-polarity microtubule-based motors cytoplasmic dynein-1 and KIF1C
Agnieszka A. Kendrick, Andrea M. Dickey, William B. Redwine, Phuoc Tien Tran, Laura Pontano Vaites, Monika Dzieciatkowska, J. Wade Harper,  and Samara L. Reck-Peterson
J Cell Biol . 2019; 218 (9): 2982–3001. doi: 10.1083/jcb.201812170

 Estradiol enables chronic corticosterone to inhibit pulsatile luteinizing hormone secretion and suppress KISS1 neuronal activation in female mice
Kreisman, M. J., McCosh, R. B., Tian, K., Song, C. I., & Breen, K. M. (2019).
Neuroendocrinology, 110(6), 501–516. https://doi.org/10.1159/000502978

Insulin‐induced hypoglycaemia suppresses pulsatile luteinising hormone secretion and arcuate Kiss1 cell activation in female mice
Richard B. McCosh, Michael J. Kreisman, Katherine Tian, Bryan S. Ho, Varykina G. Thackray, and Kellie M. Breen
J Neuroendocrinol.  2019;  31:e12813. doi: 10.1111/jne.12813